MALAT1 can be induced in tumor cells under hypoxic conditions 121, Yuan et al. first compared the expression of MALAT1 in 5-FU-sensitive and resistant HCC cell lines, and the results revealed that MALAT1 mRNA levels and the levels of hypoxia-inducible factor (HIF)-2α were significantly increased in 5-FU resistant cells 16. The gene discussed is EPAS1; the disease is hepatocellular carcinoma.