To determine the impact of IL-6R signaling on intestinal proliferation and repair under exogenous stress, it was exposed IL-6Rfl and IL-6RΔIEC mice to DSS, the results indicated that the mice of both genotypes started to lose weight, but IL-6RΔIEC mice seemed to cope better with DSS-induced colitis than WT as they significantly lost less weight than IL-6Rfl mice. This evidence concerns the gene IL6R and colitis.