PRPF6 and Familial prostate cancer: In good agreement with upregulation of AR-FL and AR-Vs expression by PRPF6 (Figure 5), we found that mRNA expression of PRPF6 was positively correlated with that of AR in prostate cancer patients of TCGA database using the Gene Expression Profiling Interactive Analysis (GEPIA) 36, suggesting PRPF6 participate in regulation of AR transcription in clinical prostate cancer tissues (Figure 7A).