Additionally, selenoenzyme glutathione peroxidase 4 (Gpx4), due to its unique activity to prevent the uncontrolled peroxidation of phospholipids (PLs), has been proposed to be the most central downstream ferroptosis regulator, and was also remarkably repressed in the iron overloaded cells and muscle tissue of sarcopenia mice in this study. Here, GPX4 is linked to sarcopenia.