HMOX1 and cancer: With respect to the link, study shows that the treatment of cancer cells with DAS, DATS, and diallyl tetrasulfide can significantly reduce tumor growth mechanistically by upregulating heme oxygenase-1 (HO-1) expressions through MAPK and PI3K-mediated activation of nuclear factor erythroid-2 related factor-2 (Nrf-2) pathway 59-61.