Our results indicated that the infiltration levels of CD4 Naive, CD8 Memory, Monocytes CD16 and pDC were decreased in ccRCC compared with adjacent normal tissues, and the infiltration levels of CD4 Memory, CD8 Effector, Th cell, DC, NK and Plasma were increased in ccRCC than that in adjacent normal tissues. This evidence concerns the gene CD4 and nonpapillary renal cell carcinoma.