Our results indicated that the infiltration levels of CD4 Naive, CD8 Memory, Monocytes CD16 and pDC were decreased in ccRCC compared with adjacent normal tissues, and the infiltration levels of CD4 Memory, CD8 Effector, Th cell, DC, NK and Plasma were increased in ccRCC than that in adjacent normal tissues. The gene discussed is CD8A; the disease is nonpapillary renal cell carcinoma.