ACE2 and nonpapillary renal cell carcinoma: The following multivariate Cox regression analysis results demonstrated that M1, Stage III/IV and Grade 3/4 were independent predictors of shorter DFS, while increased ACE2 expression (HR: 0.8023, 95%CI: 0.7375-0.8729, P<0.0001) was independent predictor of longer RFS in ccRCC patients (Table 3).