Downregulated HSF5 expression was also observed in various cancers, including bladder urothelial carcinoma (BLCA), colon adenocarcinoma (COAD), kidney chromophobe (KICH), lung squamous cell carcinoma (LUSC), prostate adenocarcinoma (PRAD) and thyroid carcinoma (THCA). The gene discussed is HSF5; the disease is colon adenocarcinoma.