SUPT4H1 and amyotrophic lateral sclerosis: Targeting the transcription elongation factor Spt4 to reduce the expression of a single gene product, SUPT4H1 or SUPT5H, can reduce the three main pathological features of C9FTD/ALS - sense RNA foci, antisense RNA foci, sense and antisense extended transcripts and their translated dipeptide repeats (DPR) products - and reduce degradation in animal models.