INS and Insulin resistance: One of the reasons for the association of rs4402960T with T2DM could be the association of the T allele of rs4402960 with insulin sensitivity, which affects all glucose tolerance phenotypes, or the significantly increased insulin resistance of genotype TT, determined by homoeostasis model assessment for insulin resistance (HOMA-IR) and increased levels of IGF2BP2 mRNA in adipocytes 5, 6.