Although no previous studies have given any supporting evidence directly indicating the expression and function of CKS2 in HBV-related HCC, some researchers have investigated its relationship with HCC and viral infection-induced woodchuck HCC. CKS2 is overexpressed in HCC at both mRNA and proteins levels and upregulates in woodchuck HCC at mRNA level 36 and its overexpression is related to poor differentiation and the aggressive behaviour of HCC 36. This evidence concerns the gene CKS2 and hepatocellular carcinoma.