NFE2L2 and COVID-19: RESV is demonstrated to be neuroprotective in several ways, including stimulating the Nrf2 pathway and reducing NF-kB activity 58, activating Sirt1 signaling in neurons 59, etc. Nrf2, a member of the cap'n'collar (CNC) basic-leucine-zipper transcription factors, and its signaling are also of interest for COVID-19 patients because Nrf2 serves as an anti-inflammatory, anti-apoptotic, and antioxidant factor through different pathways 60.