KEGG analysis found that these targeted genes were enriched in Cellular senescence, Proteoglycans in cancer, p53 signaling pathway, etc., while significant enrichment of E2F_Targets, G2M_Checkpoint, mTORC1_Signaling, MYC_Target_V1 pathway was revealed by Hallmark pathway enrichment analysis (Fig. 4, andTable S4). This evidence concerns the gene TP53 and cancer.