Our analysis demonstrated that PPAR and lipid metabolism-related pathways (Figure 1), such as “Regulation of lipid metabolism PPAR regulation of lipid metabolism” and “Regulation of lipid metabolism RXR-dependent regulation of lipid metabolism via PPAR, RAR, and VDR” (Figure 2) were important in ampullary cancer. Here, VDR is linked to carcinoma of the ampulla of vater.