Moreover, MetaCore results indicated that “Regulation of lipid metabolism PPAR regulation of lipid metabolism (p = 1.592 × 10-5) and “Regulation of lipid metabolism RXR-dependent regulation of lipid metabolism via PPAR, RAR and VDR” (RAR, retinoic acid receptor; VDR, vitamin D receptor; p = 4.734 × 10-5) ranked in the top significant pathways in ampullary cancer (arrow in Figure 2A). The gene discussed is VDR; the disease is carcinoma of the ampulla of vater.