Furthermore, we observed that TP53 (66%), TTN (35%), FAT1 (21%), CDKN2A (20%), MUC16 (17%), CSMD3 (16%), NOTCH1 (16%), PIK3CA (16%), SYNE1 (15%), and LRP1B (14%) were the top 10 mutated genes in HNSCC (Figure 1G). This evidence concerns the gene PIK3CA and head and neck squamous cell carcinoma.