Under T2DM-related hyperglycemic conditions, islet amyloid polypeptide (amylin) is susceptible to form oligomeric species and amyloidogenic aggregates that have been described to mediate dysfunction and apoptosis in pancreatic β-cells that secrete insulin and have been linked to insulin insufficiency in T2DM subjects 5-8. This evidence concerns the gene INS and type 2 diabetes mellitus.