For instance, BRAF inhibition results in a rapid recovery of phospho-ERK (pERK) signaling result in drug resistance 41; activation of JNK is associated with cell proliferation and shorter relapse-free period for patients with superficial spreading melanomas 42, 43; p38 activity contribute to metastasis result in poor prognosis 44. This evidence concerns the gene EIF2AK3 and superficial spreading melanoma.