FOXO4 and cyclic hematopoiesis: Our results showed that miR-30a, miR-499 and miR-216b decreased significantly more, and miR-23b or miR-216a increased in CH in vivo, while FoxO4 increased more, which was reversed by NPY-I, and NPY-I increased miR-216b and miR-499 expression in Sham rats (Fig. 4A, B).