Importantly, TN and TNP tumors, but not Vector hNSCs, frequently invaded bilateral SVZs of the host mice, a phenomenon associated with increased recurrence and decreased survival in patients with GBM (Fig. 2a, b; Supplementary information, Fig. S2a, b).25,26 A significant portion of invading cells in the white matter and the SVZ expressed OLIG2 and Ki67 (Fig. 2c–e). Here, OLIG2 is linked to glioblastoma.