Genetic drivers such as EGFR and PDGFRA were proposed to influence the distribution of cellular states in human GBM.5 Thus, we sought to determine genetic alterations that drive the fate switches of NSC-like cells by analyzing the time-series deep WES (400X) data from TNP, TN, and Vector samples (Fig. 3a). Here, PDGFRA is linked to glioblastoma.