Our previous study revealed that the RNA-binding protein RBM25 induces circAMOTL1L biogenesis by directly interacting with circAMOTL1L, p53 upregulates circAMOTL1L expression through activating the RBM25 gene, whereas p53 downregulation in PCa cells facilitates epithelial-mesenchymal transition (EMT) [24]. Here, RBM25 is linked to posterior cortical atrophy.