Gandellini et al. reported that miR-205 exerts a tumor-suppressive effect in human prostate by counteracting epithelial-to-mesenchymal transition and reducing cell migration/invasion, in part through down-regulating ErbB3, E2F1, E2F5, ZEB2 and protein kinase Cε, and ectopical expression of miR-205 can halt PCa progression by the downregulation of E2F5 and E2F1 [48]. Here, E2F1 is linked to posterior cortical atrophy.