This is not only very interesting in the context of bacterial infection but also potentially important for SARS-CoV-2 infection—although more active tPA mitigates the risk for developing complications of thromboembolism nature, insufficient coagulation could compromise the body’s ability to limit the pathogen locally, predisposing the individual to viremia of higher viral load and likely more severe systemic infection. Here, PLAT is linked to bacterial infectious disease.