IL6 and cancer: The types of immune cells associated with TME are mostly associated with cytokine production, broadly classified as anti-tumorigenic (IL-12, IFN-γ, TRAIL), pro-tumorigenic (IL-6, IL-23, IL-10, IL-17), and cytokines with direct roles on cancer cells’ signaling (TGF-β, TNFα, IL-6, FasL).