VEGFA and POEMS syndrome: The possibility of increased intracranial pressure, overproduction of inflammatory mediators with microangiopathy, direct disc infiltrations, or elevated abnormal proteins has been proposed and debated over the years.12,13 It has been postulated that as VEGF is a pro-inflammatory and potent angiogenic factor, its overproduction in POEMS syndrome leads to abnormal and leaky endothelial cell proliferation that subsequently leads to plasma leakage.