Whilst the pathogenesis of CSD and POEMS syndrome may differ, use of corticosteroids may help control some degree of intraocular inflammation and optic neuropathy by inhibiting migration of inflammatory cells and mediators, especially prostaglandins, leukotrienes, and cytokines (importantly VEGF-A) in the retina, which further reduces vascular leakage and edema.8 The gene discussed is VEGFA; the disease is optic nerve disorder.