Activating BRAF mutations can be found in up to 50% of CM, and among BRAF mutation-bearing samples, the ratio of BRAF V600E to BRAF V600K is nearly 4:1.37,53,54 It is debatable whether BRAF mutations are of prognostic significance, but a population-based study in Denmark has correlated BRAF mutation status with male gender, younger age, sun-exposed tumors (which included bulbar conjunctiva or caruncle), mixed or non-pigmented color, absence of PAM, and CM of nevi origin.2 Here, BRAF is linked to cutaneous mastocytosis.