As a contribution to clinical interpretation of the copy number alterations in CM, single nucleotide polymorphism array has been conducted in a multi-center study in 59 CM to study the correlation between copy number alterations and clinical outcome.66 Four tumor suppressor genes (NEURL1, SUFU, PDCD4, C10orf90) which were affected by deletions of chromosome 10q24.32-26.2 were found to be significantly related to CM metastasis. The gene discussed is PDCD4; the disease is cutaneous mastocytosis.