NF1 and cutaneous melanoma: A more recent large cohort of 63 CMs demonstrated NF1 mutations as the most frequent mutation in CM (33%), followed by activating mutations of BRAF and RAS genes, all of which induce activation of the MAPK pathway.58 The authors proposed a genetic classification of CM similar to cutaneous melanoma, including BRAF-mutated, RAS-mutated, NF1-mutated and triple wild-type CMs, implying mutual exclusion of each entity.58