PDPN and neoplasm: A study of intratumoral lymphatic vessel density by staining lymphatic vascular endothelial hyaluronan receptor-1 and podoplanin as lymphatic endothelial markers showed that higher intratumoral lymphatic vessel density was correlated with higher tumor thickness and larger tumor diameter, as well as lower recurrence-free and higher melanoma-related death rates.48 The same markers were used to compare intra- and peritumoral lymphatic vessel density in C-MIN with and without atypia and in CM.