As for other mutations that were detected in CM, whole exome sequencing in excised material of 5 CM patients showed that in addition to BRAF, NRAS, and NF1 mutations, CM harbors previously unreported mutations in EGFR, APC, TERT, and other cancer-associated genes and the C→T mutation signature consistent with UV-induced DNA damage. The gene discussed is NRAS; the disease is cutaneous mastocytosis.