Table 1 shows the patient and clinicopathologic characteristics of the N = 85,982 individuals included in the analysis set, including N = 1650 who did not receive local intervention, and N = 17,714 patients with low-risk features (Hispanic and non-Hispanic white women aged 50–69 at diagnosis, with ER+, grade 1 + 2, ≤ 2 cm DCIS lesions). Here, ESR1 is linked to ductal breast carcinoma in situ.