Some Immune system-related terms and pathways were largely identified, including ECM-receptor interaction, PI3K-Akt signaling pathway, focal adhesion, TGF-beta signaling pathway, human papillomavirus infection, extracellular matrix organization, skeletal system development, collagen-containing extracellular matrix, endoplasmic reticulum lumen, extracellular matrix structural constituent, and glycosaminoglycan binding. The gene discussed is PIK3CA; the disease is human papilloma virus infection.