Adjusted model 3 includes all variables considered in adjusted model 2, plus hypertension, hypercholesterolemia, BMI, diabetes mellitus, triglycerides, LDL, HDL, AST, ALT, and alkaline phosphatase which could act as potential intermediates in the causal pathways describing the relationship of opium use with IHD and MI diseases. This evidence concerns the gene GPT and diabetes mellitus.