GDF15 and neuroendocrine neoplasm: However, some hG::Bfl/wt::Nfl/wt, hG::Bfl/wt::Nfl/fl and hG::Bfl/fl::Nfl/wt mice died due to neuroendocrine tumors of the pancreas and the pituitary gland as already reported for hGFAP-cre::lslMYCN mice (data not shown) [28].