The microarray data also revealed that the expression level of vasculogenesis-related genes, such as VEGFA, stromal derived factor-1 (SDF-1), C-X-C motif ligand 12 (CXCL12), and angiopoietin 2 (ANGP2), of KNS1451 were higher than those of KNS1435 (Supplementary Fig. 2b).Microsatellite analyses revealed the glioma-related LOH on 17p, 19q, and chromosome 10 (Supplementary Table 1). Here, ANGPT2 is linked to central nervous system cancer.