The TLR3/IFN-β/MDA5/CXCL10 axis demonstrated by our study corroborates previous findings of the role of MDA5 in regulating CXCL10 expression in glomerular mesangial cells [15], brain microvascular endothelial cells [26], and hepatocellular carcinoma cells [27]. This evidence concerns the gene TLR3 and hepatocellular carcinoma.