Neural cell adhesion molecule L1 (L1CAM), one of the protein products of the RELA fusion gene, is of interest, and Nambirajan and Witt reported that programmed death ligand-1 (PD-L1) is upregulated in ST-RELA ependymomas (Witt et al. 2018; Nambirajan et al. 2019). This evidence concerns the gene L1CAM and ependymoma.