Histologic grade and age are considered very important clinical prognostic factors; therefore, we conducted a progressive analysis of the effects of PD-L1 expression and EOR on the ependymoma (WHO grade II) and anaplastic ependymoma (WHO grade III) groups, as well as on the age groups ≥ 12 years and < 12 years. The gene discussed is CD274; the disease is anaplastic ependymoma.