IDH2 and acute myeloid leukemia: Some studies [16, 35] believe that ASXL1, EZH2, SRSF2, and IDH1/IDH2 are five “prognostically detrimental” mutated genes in PMF, and patients carrying any of these mutated genes belong to the high-molecular risk category (HMR); such patients have shortened OS and increased prevalence of AML.