Increased metabolic activity in R26Cyp1a1 mice faithfully phenocopied Ahr deficiency, leading to exacerbated skin inflammation, which in turn was attenuated by the inhibition of CYP1A1 enzymatic activity by α-NF, a potent CYP1 inhibitor (Wincent et al., 2012), also described in early studies as a partial AHR antagonist (Merchant et al., 1993). Here, AHR is linked to hyperinsulinemic hypoglycemia, familial, 4.