Importantly, by positional mapping of likely functional variants, we identified genes related to the immune system (CXCL6, MEF2C, ITPR3, UBE2D1, C7orf73, STIM1, PNP, CRK and SIRPB1), cancer and cell cycle (TERT, BAK1, CDK6, CDK10, SUFU, FANCI, MDFIC, JMJD1C, USP7, BIK) and mitochondrial function (MFN2, TFAM, DGUOK, USP30, CREB5, POLG) to be potentially involved in governing mtDNA abundance in blood (Fig. 3). The gene discussed is FANCI; the disease is cancer.