CRHR2 and Anxiety: Second, the behavioral effects of Ucn3/CRFR2 might depend on increased expression of Ucn3, as there are reports demonstrating that stress increases Ucn3 mRNA levels (Venihaki et al., 2004) and increased anxiety-like behavior has been reported after overexpression of Ucn3 in PeFA neurons (Kuperman et al., 2010).