CRHR2 and Anxiety: However, differently from CRFR2-mutant mice (Bale et al., 2000; Bale and Vale, 2003; Coste et al., 2000), Ucn3-deficient mice did not show impairments in hypothalamic-pituitary-adrenal axis regulation and anxiety- or depression-related behaviors (Deussing et al., 2010).