CRHR2 and Anxiety: Accumulating evidence has suggested that PeFA Ucn3 and its receptor, CRFR2, play an important role in energy homeostasis (Chen et al., 2012; Kuperman et al., 2010) and stress-related responses, including anxiety-like behaviors (Anthony et al., 2014; Kuperman et al., 2010; Venihaki et al., 2004).