Mutations of the protrudin gene (ZFYVE27) are responsible for a subset of cases of HSP (Mannan et al., 2006; Zhang et al., 2012; Hashimoto et al., 2014; Hubner and Kurth, 2014; Powers et al., 2017; Fowler et al., 2019). This evidence concerns the gene ZFYVE27 and hereditary spastic paraplegia.