The most significantly enriched molecular functions included “protein serine/threonine kinase activity,” “Rab GTPase binding,” and “protein serine/threonine/tyrosine kinase activity,” In terms of KEGG pathway, the main significant pathways included “autophagy,” “small cell lung cancer,” “Toll-like receptor signaling pathway,” “pancreatic cancer,” “ErbB signaling pathway,” “colorectal cancer,” “endocrine resistance,” and “hedgehog signaling pathway.” These results indicated that the regulatory network may contribute to therapeutic resistance of PC through multiple signal pathways. Here, EGFR is linked to pachyonychia congenita.