Accumulated clinical evidence had demonstrated that high levels of Dkk-1 were correlated with poor overall survival in various cancers, which suggested that Dkk-1 might be as a prognostic marker (Politou et al., 2006; Yang et al., 2013; Dong et al., 2014; Rachner et al., 2014). The gene discussed is DKK1; the disease is cancer.