The TF–target gene network analysis uncovered an unexpected scenario where both correlation-enhancing genes (with higher correlation in the tumor) and -repressing genes (with lower correlation in the tumor) were targeted by STAT1 (6A), STAT3 (6B), KDM1A (6C), PML (Supplementary Figure 6A) and RELA (Supplementary Figure 6B). This evidence concerns the gene PML and neoplasm.