TREM2 and Alzheimer disease: Significantly increased levels of Muribacterium and Lactobacillus in POCD mice, genera that were deficient in POCD-APP/PS Mice. Attenuated levels of the pro-inflammatory cytokines IL-6, of IL-1β, and the immunosuppressive cytokine IL-10. Also increased ZO-1 levels in epithelium and hypothalamus tissue countering the leaky gut and leaky brain phenotype of AD-mice. Restored TREM2 levels, leading to the normalization of microglia neuroinflammatory response. Induces growth of Bifidobacterium adolescentis and Bifidobacterium longum, the former being documented for its neuroinflammatory properties