Significantly increased levels of Muribacterium and Lactobacillus in POCD mice, genera that were deficient in POCD-APP/PS Mice. Attenuated levels of the pro-inflammatory cytokines IL-6, of IL-1β, and the immunosuppressive cytokine IL-10. Also increased ZO-1 levels in epithelium and hypothalamus tissue countering the leaky gut and leaky brain phenotype of AD-mice. Restored TREM2 levels, leading to the normalization of microglia neuroinflammatory response. Induces growth of Bifidobacterium adolescentis and Bifidobacterium longum, the former being documented for its neuroinflammatory properties. This evidence concerns the gene TJP1 and Alzheimer disease.