STAT3 and colitis: Naringin (4′,5,7-trihydroxyavanone-7-rhamnoglucoside), a major flavanone glycoside that occurs naturally in citrus fruits, inhibits the severity of colitis and CRC development through regulation of the MDSCs’ immunosuppressive function via the NF-κB/IL-6/STAT3 axis in colorectal tissues (120).