CASP1 and colorectal carcinoma: While docosahexaenoic acid (DHA) has been shown to inhibit caspase-1 activity in 5-fluorouracil (5-FU) treated MDSCs, a negative relationship between the DHA content in plasma and the induction of caspase-1 activity in MDSCs of CRC patients treated with 5-FU-based chemotherapy has been reported (130).