PDK1, a downstream target of hypoxia inducible factor 1 alpha (HIF1α), is upregulated in a number of cancers including ovarian cancer (OCa) (36), gastric cancer (GCa) (37, 38), colorectal cancer (CRCa) (39), PCa (40), and acute myeloid leukemia (AML) (41). Here, HIF1A is linked to temporal arteritis.