HIF1A and colorectal cancer: PDK1, a downstream target of hypoxia inducible factor 1 alpha (HIF1α), is upregulated in a number of cancers including ovarian cancer (OCa) (36), gastric cancer (GCa) (37, 38), colorectal cancer (CRCa) (39), PCa (40), and acute myeloid leukemia (AML) (41).