PDK1–3 are described as oncogenes in different cancer types where their high expression is associated with EMT and metastasis, higher proliferation and migration, and most relevantly with therapy resistances, such as to 5-FU in CRCa and GCa, cisplatin in HNSCCa and OCa or paclitaxel in NSCLCa. Here, PDK1 is linked to oculocutaneous albinism.