PDK1, a downstream target of hypoxia inducible factor 1 alpha (HIF1α), is upregulated in a number of cancers including ovarian cancer (OCa) (36), gastric cancer (GCa) (37, 38), colorectal cancer (CRCa) (39), PCa (40), and acute myeloid leukemia (AML) (41). Here, PDK1 is linked to posterior cortical atrophy.