PDK1, a downstream target of hypoxia inducible factor 1 alpha (HIF1α), is upregulated in a number of cancers including ovarian cancer (OCa) (36), gastric cancer (GCa) (37, 38), colorectal cancer (CRCa) (39), PCa (40), and acute myeloid leukemia (AML) (41). This evidence concerns the gene HIF1A and cancer.