TYR and vitiligo: Tyrosinase (TYR) transcript was expressed in the healthy controls and the vitiligo case, while the mean trended lower in the VKH cases but showed no statistical difference from controls (Figure 1B).IGFBP5, which is known to mediate fibrosis (23), and FOXO1, which is associated with adipogenesis (24), were significantly downregulated in lesional skin (Figure 1B).