Previous studies have suggested that HOXB3, GH1 and KIR2DL4 are involved in autoimmune disease such as Thyroid-associated orbitopathy (TAO), Type 1 diabetes (T1DM), and Systemic lupus erythematosus (SLE) (24–26). This evidence concerns the gene KIR2DL4 and thromboangiitis obliterans.