PD-1 and Lag-3 were similarly upregulated selectively in tumor-recognizing NKG2D-CAR T cells, which may be more reflective of T-cell activation than exhaustion, given robust NKG2D-CAR functionality observed in several assays, but suggests that NKG2D-CAR T cell response could be further enhanced in combination with checkpoint blockade or genetic modification strategies. Here, LAG3 is linked to neoplasm.