KLRK1 and acute lymphoblastic leukemia: We observed potent NKG2D-CAR T cell responses to AML and T-ALL cell lines and showed that these were mediated specifically by the NKG2D-CAR interaction with NKG2D-ligands, given that similar effects were not mediated by control T-cells, were abrogated by preincubation of NGK2D-CAR T cells with NKG2D-blocking mAb and were not observed in response to NKG2D-ligand negative targets.