GSDME and infection: Gasdermin family comprises six paralogous genes: GSDMA, GSDMB, GSDMC, GSDMD, GSDME (also known as DFNA5), and PJVK (also known as DFNB59) and are components of a cell death program (Broz et al., 2020) Both gasdermin B (GSDMB) and gasdermin E (GSMDE) act as tumor suppressors via triggering pyroptosis and promote tumor clearance, while GSDMD is a crucial executor of pyroptosis in anti-infection immunity (Pandeya et al., 2019; Wang et al., 2020; Zhou et al., 2020).