LAMA3 and neoplasm: They selected on chromosome 18 as laminin alpha 3 (LAMA3), serpin peptidase inhibitor clade B member 5 (SERPINB5), and factor receptor superfamily member 11a NFKB activator (RANK or TNSFRSF11A), suggesting that epigenetic silencing could be the possible second step in tumor development upon chromosome 18 loss (33–35).