NFASC and metabolic dysfunction-associated steatohepatitis: The targeting of apoptotic caspases such as the pan-caspase inhibitor Emricasan, while effective in preclinical studies (114), did not improve clinical aspects nor NASH features in NASH patients with fibrosis but, to the contrary, could aggravate fibrosis and hepatocyte ballooning (115, 116) (ENCORE-PH and ENCORE-NF trials; Phase II).