Lanifibranor also meets multiple key secondary endpoints including fibrosis improvement (by at least one stage without NASH worsening), insulin resistance (decreased in insulin, fasting glucose, Hb1Ac), lipid profiles (decreased in insulin, fasting glucose, Hb1Ac and triglycerides and increased in HDL), and liver injury (decreased in ALT, AST, and GGT). The gene discussed is INS; the disease is metabolic dysfunction-associated steatohepatitis.