Yi et al. (95) found that CD4+ T cells exhibit enhanced inflammatory Th1 and Th17 responses in MuSK+ MG, although no difference was found in either frequencies or CD39 expression of FoxP3+ Tregs between MuSK+ MG and healthy controls, suggesting that increased pro-inflammatory T cell responses were not attributed to numerical or functional defects of Tregs. This evidence concerns the gene CD4 and myasthenia gravis.