Setiadi et al. (2020) showed that inflammation plays a role in maintaining hypertension in the Goldblatt model, as the treatment with pentoxifylline, a tumor necrosis factor-α (TNF-α) synthesis inhibitor, evoked a drop in BP and rSNA, as well as a reduction in neuronal activity in the PVN of 2K1C rats. This evidence concerns the gene TNF and hypertensive disorder.