Moreover, angiotensin II-induced microglial activation and hypertension in the PVN were reversed by intracerebroventricular infusion of minocycline, an anti-inflammatory antibiotic, and another study showed that total renal denervation decreased microglial activation and reactive oxygen species in the cortex, white matter, and PVN of stroke prone spontaneously hypertensive rats (SHRSP; Shi et al., 2010; Nakagawa et al., 2013). This evidence concerns the gene AGT and stroke disorder.