AGT and hypertensive disorder: Previous studies showed that oxidative stress induced by angiotensin II-NADPH oxidase pathway in the RVLM and PVN plays a critical role in the development of hypertension in the 2K1C model (Oliveira-Sales et al., 2009; de Oliveira-Sales et al., 2010), and total renal denervation was capable of reversing it (Nishi et al., 2019).