Six single-arm studies reported secondary bacterial infections, with an overall rate of 14.35%, which was also remarkably lower than that of the SOC group (14.35 vs. 17.36%, p < 0.0001) and the anti-IL-6 signaling group (14.35 vs. 25.98%, p < 0.0001) in the meta-analysis. Here, IL6 is linked to bacterial infectious disease.